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Stem cell study could reduce animals used in research
The stem cell study could curb the need for tissue obtained from animals.
Researchers aim to generate a continuous supply of pig blood cells in the laboratory.

A new method of generating pig blood cells in the laboratory, to help limit the number of animals used in research, is being developed by scientists at the University of Edinburgh's Roslin Institute.

Researchers say their study aims to better understand techniques for generating white blood cells (macrophages) from pig stem cells in the lab. The research is being supported by the National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs).

The blood cells will be used to test vaccines and treatments for highly contagious diseases, including African Swine Fever Virus (ASFV), and Porcine Reproductive and Respiratory Syndrome Virus (PRRSV).

Dr Tom Burdon from the Roslin Institute, said: “The ability to generate a continuous supply of pig blood cells from stem cells in the lab would be a valuable tool in helping to develop vaccines against devastating livestock diseases, with significantly reduced need for tissue from animals.”

Working with the University of Edinburgh’s Centre for Regenerative Medicine and the APHA, researchers seek to further understanding of how specific cells are derived efficiently from stem cells.

Their study will explore how white blood cells develop from pig stem cells, to identify key stages as they develop into blood cells. They hope to devise a method of arresting cell development, and for controlling the final stage of differentiation into white blood cells.

Researchers believe the technique has the potential to provide a large-scale, continuous supply of blood cells for the testing and development of therapies. It could, thereby, curb the need for tissue obtained from animals.

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Practices urged to audit neutering data

News Story 1
 RCVS Knowledge has called on vet practices to audit their post-operative neutering outcomes.

It follows the release of the 2024 NASAN benchmarking report, which collates data from neutering procedures performed on dogs, cats and rabbits.

The benchmarking report enables practices in the UK and Ireland to compare their post-operative outcomes to the national average. This includes the rate of patients lost to follow-up, which in 2024 increased to 23 per cent.

Anyone from the practice can submit the data using a free template. The deadline for next report is February 2026.

Visit the RCVS Knowledge website to complete an audit. 

Click here for more...
News Shorts
UK's BSE risk status downgraded

The WOAH has downgraded the UK's international risk status for BSE to 'negligible'.

Defra says that the UK's improved risk status recognises the reputation for having the highest standards for biosecurity. It adds that it demonstrates decades of rigorous animal control.

Outbreaks of Bovine Spongiform Encephalopathy, also known as mad cow disease, have previously resulted in bans on Britain's beef exports.

The UK's new status could lead to expanded trade and better confidence in British beef.

Christine Middlemiss, the UK's chief veterinary officer, said: "WOAH's recognition of the UK as negligible risk for BSE is a significant milestone and is a testament to the UK's strong biosecurity measures and the hard work and vigilance of farmers and livestock keepers across the country who have all played their part in managing the spread of this disease.