Your data on MRCVSonline
The nature of the services provided by Vision Media means that we might obtain certain information about you.
Please read our Data Protection and Privacy Policy for details.

In addition, (with your consent) some parts of our website may store a 'cookie' in your browser for the purposes of
functionality or performance monitoring.
Click here to manage your settings.
If you would like to forward this story on to a friend, simply fill in the form below and click send.

Your friend's email:
Your email:
Your name:
 
 
Send Cancel

New genetic test for DEPOH in sighthounds
DEPOH is an important health problem in certain sighthound breeds.

The test will allow vets to target the use of preventative medication.

Researchers at Washington State University, supported by the Scottish Deerhound Club of America, have developed a new genetic test that can identify dogs at risk of a condition known as delayed postoperative haemorrhage (DEPOH). The disorder can result in excessive bleeding and bruising in the hours and days after major surgery.

The test was developed following a study of 269 privately owned deerhounds. The dogs were evaluated with an objective of identifying genes associated with DEPOH.

The researchers used genome-wide association analysis to identify a single region on chromosome 9 that contained 40 candidate genes. Further screening of the candidate genes was performed and only the DEPOH gene was identified as being directly linked to the pathophysiology of the disorder.

DEPOH is a potentially fatal disorder that can vary in severity from minor bruising to life-threatening haemorrhaging. The condition typically occurs one to four days after major surgery when blood clots begin to break down too soon, in a process called hyperfibrinolysis.

First identified in racing greyhounds in 2007, DEPOH is an important health problem in certain sighthound breeds, including Scottish deerhounds and greyhounds. Following the identification of the DEPOH gene, the mutation has been discovered in additional sighthounds such as Italian greyhounds and salukis, as well as other breeds including golden retrievers and border collies.

Dogs with a mutation of the DEPOH gene are at higher risk than other dogs of developing the condition post surgery. The new test will allow veterinary surgeons to administer antifibrinolytic drugs to those that test positive for the gene before any surgery.

Previously, veterinary surgeons would have had to administer preventative medication indiscriminately, which can be costly and lead to adverse reactions.

Health and genetics commission chair for the Scottish Deerhound Club of America Dr. John Dillberger said: “Now pet owners can test their dog at any time in its life to understand whether it is at risk.

“And if it is, before planning any scheduled or elective surgery, they can make sure the surgeon is aware of it and prepare accordingly. This will help save the lives of pets.”

The study has been published by the Journal of Veterinary Medicine.

Become a member or log in to add this story to your CPD history

FIVP announces third series of Practice Matters

News Story 1
 The Federation of Independent Veterinary Practices (FIVP) has announced a third season of its podcast, Practice Matters.

Hosted by Ian Wolstenholme, series three will focus on the Competition and Markets Authority (CMA) investigation, including a discussion about some of the expected impacts on independent veterinary colleagues.

Episode one launches on 13th January with guests Drs David Reader and Scott Summers, who will draw on their research into the CMA investigation and provide insights into themes such as transparency, pricing and consumer trust.

Ian Wolstenholme said: "In its third series, we will try and hone in on what the changes will mean in reality for independent practices with advice and guidance on implementation and delivery, drawing on the experience of our own team and other experts in the profession. Hope you can join us soon!" 

Click here for more...
News Shorts
Survey seeks ruminant sector views on antimicrobial stewardship

A new survey is seeking views of people working in the UK ruminant sector on how to tackle the challenge of demonstrating responsible antibiotic stewardship.

Forming part of a wider, collaborative initiative, the results will help identify the types of data available so that challenges with data collection can be better understood and addressed.

Anyone working in the UK farming sector, including vets and farmers,is encouraged to complete the survey, which is available at app.onlinesurveys.jisc.ac.uk